I think Domination is the only good way to play 3 (and probably 5 player), and the best way to play any number greater than 2.
That said, I vastly prefer playing Arena, and playing 2p games. MW is a 2p game to me, nothing else. If we have 4p or 6p I'd rather we break up in to 2 or 3 Arena games. So 3p is it's only real niche, and we just organise game days to have even numbers.
Shortening the game, and/or putting a clock on it is a big negative for me, not a positive.