I think it'll be worth picking up. It'll be most useful for getting new players interested in the game or enticing casual/younger gamers. But also useful for pulling out to play when you have a limited amount of time available.
Obviously strategies, metagame, cards and the rules are all going to be different since there are only 3 zones. But I'm pretty sure I'll end up getting it just for the fact that it'll be an easy way to teach people how to play as a stepping stone into the real game. If it's actually good, that'll make it even more worth it.
It was mentioned that "All cards from the Academy work with the other sets, but not all cards from the original sets work with the Academy expansion." So I'm sure they took into consideration that some cards are going to be really OP if they could be used in this.